Barbara, Your experience from IP chemo sounds very familiar. While my treatments ended March 2002, I definitely remember how uncomfortable the IP chemo made me feel. It makes sense that the direct flow of meds into the peritoneal should do more good as well as more temporary damage. My white count dropped more so than on IV and I had ongoing bowel issues, mainly constipation, and that queasy bloated feeling. The sheer anxiety of the whole process going smoothly is enough to tie your stomach in knots. BUT (in bold letters) 4 1/2 years after my surgery in June 01 with Stage III OVCA at age 44, I am living well cancer free. While I often questioned my ability to withstand the treatments and recover fully, Dr. Brisotw, in his patient steady way, let me know repeatedly that I was strong enough. Best wishes to you for your remaining treatments. I am more than happy to communicate personally with you or anyone else out there, or through this board. Original Message: »» I was diagnosed with ovarian cancer in January, 2005. Since my cancer did not appear to originate in the ovaries themselves, but in the peritoneal cavity, it is classed as primary peritoneal cancer. Debulking surgery was followed by six cycles of IV carboplatin and taxol chemo. I am happy to report that my CA-125 numbers have remained well in the normal range, starting with the third IV treatment of the initial cycle. Although my CA 125 numbers look good, at secondlook surgery I was found to have remaining microscopic cancer cells and started the IP therapy. My side effects have been minimal but have included, in addition to the bloating after treatment, abdomimal cramping and increasing fatigue. I am interested in hearing from others regarding their experience with this IP form of chemotherapy. I feel very fortunate to be receiving treatment at Johns Hopkins.